Quantcast Acelity - COLLAGEN ORC Technology


Inherent Properties of Collagen

What is Collagen?
Collagen is one of the most abundant proteins in the human body and is a major constituent of skin, bone, tendons, muscles and cartilage. Collagen has a high tensile strength and has an important role in tissue repair.1
How Collagen works:
  • It has hemostatic properties
  • A low inflammatory and antigenic response: “recognized” by cells
  • Enhances the deposition of new collagen fibers
  • Substrate for cellular adhesion and migration
  • It is bioresorbable
  • Collagen proteins and peptides stimulate cells
  • Chemotactic for neutrophils, macrophages, and fibroblasts
  • Collagen can act as a sacrificial substrate for excessive MMPs

What is ORC?

Cellulose is a major component of all plants. Once oxidized, ORC (Oxidized Regenerated Cellulose) is completely bioresorbable, and readily degrades through fluid absorption and subsequent gelling.2
In vitro studies1 have shown that ORC:

  • Has hemostatic properties
  • Stimulated cell migration and growth
  • Has bactericidal properties
  • Reduced protease activity levels, specifically elastase and MMPs
  • Scavenged free radicals and bound excess metal ions

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