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[(be)22.3(t)16.5(i)0(c)21.9(.)-233.9(P)10.2(a)0(t)26.5(i)0(e)20.7(n)12.4(t)-232.8(d)0(e)20.6(m)12.4(o)12.2(g)15.3(ra)23.5(p)13.8(h)0(i)20.9(c)13.4(s)-235.7(a)0(n)22.5(d)-235.5(c)13.4(o)12.2(m)12.4(o)12.2(r)13.4(b)0(i)24(d)0(i)22.3(t)11(i)13.9(e)12.2(s)-235.7(w)11.4(e)12.2(r)13.4(e)]TJ
0 -1.1923 TD
[(c)13.4(o)12.2(m)12.4(p)0(a)23.8(r)0(e)20.3(d)-300.6(ac)23.5(r)13.4(o)12.2(ss)-292.6(d)13.8(e)12.2(vi)23.8(ce)-294.1(t)11(y)15.3(pe)-293.7(u)12.4(s)13.6(i)13.9(n)12.4(g)-304.5(s)13.6(t)11(a)0(n)22.5(d)13.8(ar)23.5(d)]TJ
/F7 1 Tf
20.3452 0 TD
(t)Tj
/F5 1 Tf
.3414 0 TD
-.012 Tc
(-tests)Tj
-20.6867 -1.1923 TD
-.0126 Tc
[(for)-329.8(c).8(ontinuous)-329.6(va)-12.6(r)10.9(i)-12.6(a)11.4(b)-12.6(l)11.4(e)-.4(s)-324.2(a)-12.6(n)9.9(d)-324(Fis)-12.6(h)8(ers)-324.2(ex)-12.6(a)12.7(c)-12.6(t)-318.7(t)3.9(es)-12.6(t)-318.6(f).6(or)]TJ
0 -1.1869 TD
0 Tc
[(c)13.4(a)0(t)21.1(e)12.2(g)15.3(o)12.2(ri)21.9(c)13.4(a)0(l)-247(v)0(a)25.3(r)0(i)21.9(a)0(b)25.5(l)0(e)20.7(s)13.6(.)-255.5(P)10.2(e)12.2(r)13.4(ce)20.3(n)12.4(t)-254.5(w)11.4(o)12.2(u)12.4(n)12.4(d)-257.2(re)20.3(d)13.8(u)12.4(c)13.4(t)11(io)20.7(n)-253.1(w)11.4(as)]TJ
0 -1.1923 TD
[(m)12.4(e)12.2(as)23.6(u)12.4(r)13.4(e)12.2(d)-257.2(at)-249.9(4)15.5(,)-261(8)15.5(,)-261(1)15.5(2)0(,)-250.9(a)15.5(n)12.4(d)-257.2(16)-245.5(w)11.4(e)12.2(e)12.2(k)13.1(s.)-247.4(If)-247.4(a)-255.5(w)11.4(o)12.2(u)12.4(n)12.4(d)-257.2(w)11.4(a)0(s)]TJ
T*
[(c)13.4(o)12.2(m)12.4(p)0(l)22.3(e)12.2(t)11(e)12.2(l)13.9(y)-526.7(he)24.7(al)24(e)12.2(d)-528.2(o)12.2(r)-528.5(a)-526.5(s)0(u)20.6(b)15.5(je)21.4(c)13.4(t)-525.5(h)12.4(a)0(d)-518.1(d)13.8(is)22.1(c)13.4(o)12.2(n)12.4(t)11(in)20.9(u)12.4(e)12.2(d)]TJ
0 -1.1869 TD
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[(pr)-12.9(i)9(o)-.7(r)-237.9(t)3.6(o)-239.1(c).5(ompl)-12.9(e)7.8(t)3.6(i)-12.9(o)7.8(n)-233.5(o)-.7(f)-232.7(1)-12.9(6)-220.4(w)-1.5(eeks)-12.9(,)-222.3(the)-233.7(l)-12.9(a)11.1(s)-12.9(t)-226.7(o)-.7(bser)-12.9(v)10.4(a)-12.9(t)8.2(i)1(on)]TJ
0 -1.1923 TD
0 Tc
[(w)11.4(a)15.5(s)-241.1(c)13.4(ar)23.5(ri)21.9(e)12.2(d)-240.9(f)13.2(o)12.2(r)13.4(w)11.4(ar)23.5(d)-240.9(f)13.2(o)12.2(r)-241.3(t)11(h)12.4(e)-237.1(i)13.9(nt)23.5(e)12.2(n)12.4(t)11(-)13.2(t)11(o)12.2(-)13.2(t)11(re)20.3(a)15.5(t)-238.3(an)22.5(al)24(ys)23.5(i)13.9(s)13.6(.)]TJ
T*
[(W)14.3(o)12.2(u)12.4(n)12.4(d)-300.6(r)13.4(e)12.2(du)20.8(c)13.4(t)11(i)13.9(o)12.2(n)-296.5(a)0(t)-287.8(e)12.2(a)15.5(c)0(h)-288.5(t)16.5(im)20.9(e)-296.7(p)13.8(o)12.2(i)0(n)20.9(t)-292.5(w)11.4(a)0(s)-285.3(c)13.4(o)12.2(m)12.4(pa)23.8(re)20.3(d)]TJ
0 -1.1869 TD
[(be)22.3(t)16.5(w)11.4(e)12.2(e)12.2(n)-334.4(t)16.5(h)12.4(e)-334.6(t)11(w)16.8(o)-334.6(d)13.8(e)12.2(vi)23.8(c)13.4(e)-334.6(g)15.3(r)0(o)20.3(u)12.4(p)13.8(s)-333.3(u)12.4(s)13.6(in)20.9(g)-331.6(t)16.5(he)-322.2(n)12.4(o)12.2(n)12.4(p)13.8(ar)23.5(a-)]TJ
0 -1.1923 TD
[(m)12.4(e)12.2(t)11(r)13.4(ic)-281.6(Wi)22.8(l)13.9(c)0(o)20.2(x)15.3(o)12.2(n)-296.5(R)13.4(a)15.5(nk)-283.4(S)12.6(u)12.4(m)-296.5(t)16.5(e)12.2(s)0(t)24.6(.)-293.5(T)10.2(h)12.4(is)-281.4(n)12.4(o)12.2(n)12.4(p)0(a)23.8(r)0(a)23.5(m)12.4(e)12.2(t)11(-)]TJ
T*
[(r)13.4(i)0(c)-612.2(t)11(e)12.2(s)0(t)-614.9(w)16.8(as)-615.9(u)12.4(s)13.6(e)12.2(d)-625.7(b)15.5(e)12.2(c)13.4(a)0(u)22.5(s)13.6(e)-627.3(a)-618.6(S)12.6(h)12.4(ap)23.8(ir)21.9(o)12.2()0(W)24.4(i)13.9(lk)-612.5(t)11(e)12.2(s)13.6(t)]TJ
0 -1.1869 TD
-.0127 Tc
[(in)-12.7(d)8.1(i)1.2(c)-12.7(a)10.8(ted)-459.6(n)-12.7(o)12(n)-12.7(-)7.6(n)-.3(orma)-12.7(l)11.3(i)1.2(ty)-463.5(of)-460.1(the)-461.1(d)-12.7(a)11.1(t)-1.7(a)-457.9(a)-12.7(t)-452.3(e)-.5(ac)-12.7(h)-452.9(t)-1.7(ime)]TJ
0 -1.1923 TD
0 Tc
[(p)13.8(o)12.2(in)20.9(t)11(.)-342.3(T)10.2(h)12.4(e)-340(c)0(o)20.3(m)12.4(p)13.8(a)0(r)23.5(i)13.9(so)20.4(n)-339.9(o)12.2(f)-344.5(p)0(e)20.6(r)13.4(c)13.4(e)12.2(n)12.4(t)-346.6(w)11.4(o)12.2(u)12.4(n)12.4(d)-343.9(r)13.4(e)12.2(d)13.8(u)12.4(ct)19.1(i)13.9(o)12.2(n)]TJ
25.4288 64.282 TD
-.0129 Tc
[(was)-286.5(r).5(ep)-12.9(e)7.7(a)2.6(ted)-286.4(u)-.5(si)-12.9(n)8(g)-284.8(ra)-12.9(n)9.6(k)-281.6(tra)-12.9(n)9.6(sfor)-12.9(m)7.6(e)-.7(d)-286.4(d).9(ata)-284.7(i)-12.9(n)-273.8(a)-284.7(li)-12.9(n)8(-)]TJ
0 -1.1923 TD
-.0126 Tc
[(ea)-12.6(r)-270.9(m)-.2(odel)-280.5(to)-276.8(a)-12.6(d)11.2(j)-12.6(u)9(st)-283.4(for)-281(b)2.9(a)-12.6(s)11(el)-12.6(i)9.8(n)-.2(e)-282.2(w)4.2(oun)-12.6(d)-273.6(area)-12.6(s)11(.)]TJ
1.1435 -1.1869 TD
-.015 Tc
[(Finally,)-313.9(a)-319.3(KaplanMeier)-315.9(and)-315.6(L).6(ife)-311.7(T).6(able)-317.1(a).5(nalysis)]TJ
-1.1435 -1.1923 TD
-.0151 Tc
[(were)-474.4(performed)-472.8(t)1.4(o)-474.4(c)3.8(ompare)-469(the)-469(t)1.4(ime)-469(\()-1.9(i)4.2(n)-474.2(days)3.9(\))-473.4(t)1.4(o)]TJ
T*
-.0158 Tc
[(h)-3.4(e)1.9(aling)-184.8(b)-.3(e)-3.6(t).7(we)-3.6(en)-187.6(th)-3.4(e)-182.4(t).7(w)-4.4(o)-182.4(de)-3.6(vice)-187.8(grou)-3.4(ps.)-184.6(A)-2.3(ddition)-3.4(ally,)]TJ
0 -1.1869 TD
-.016 Tc
[(since)-253.1(t)-5(he)-3.8(se)-258.5(devices)-257.1(w).8(ere)-258.5(u)1.8(sed)-256.9(a)-.5(s)-257.1(a)-255.3(m)-3.6(o)1.7(no)-3.8(th)-3.6(erapy,)-255.3(we)]TJ
0 -1.1923 TD
-.0145 Tc
[(also)-311.2(compared)-315.1(the)-316.6(s)-.9(urrogate)-316.6(mark)4(er)-315.4(of)-315.6(50%)-314.2(wound)]TJ
T*
.4218 Tc
[(c)435.2(l)435.7(o)439.5(s)435.4(u)439.6(r)435.2(er)435.2(a)437.3(t)438.3(ea)437.3(t3)437.3(0d)435.6(a)437.3(y)437.1(st)432.8(oa)437.3(l)441.1(l)435.7(o)434(w)-.4(u)439.6(s)-3.6(t)438.3(o).5(p)435.6(r)440.6(e)434(d)435.6(i)435.7(c)440.7(tt)432.9(h)439.6(e)]TJ
0 -1.1869 TD
-.015 Tc
[(intend)4.2(ed)-185.5(clini)4.3(c)-1.6(al)-185.3(endpoint)-188.2(o)2.7(f)-186(w)1.8(ound)-185.5(healing.)]TJ
7.8454 0 0 6.9729 510.9731 617.3857 Tm
-.0182 Tc
[(27)6.3(,28)]TJ
10.4607 0 0 10.4607 531.666 612.7368 Tm
-.0168 Tc
(The)Tj
-21.3966 -1.1923 TD
-.0135 Tc
[(t)3(h)-1.1(ir)5.4(ty-)5.2(d).3(ay)-280(ti)5.8(me)4.2(fram)4.4(e)-283.1(i)5.8(s)-281.7(a)2(lso)-277.7(i).4(m)4.4(p).3(or)5.3(tan)4.3(t)-278.9(becau)4.3(s).1(e)-277.7(t)3(his)]TJ
T*
-.0134 Tc
[(co)4.3(ns)5.6(ider)5.5(ed)-319.4(the)-320.9(c)0(u)4.4(t)3.1(of)5.3(f)-325.3(p)5.8(oin)4.4(t)-322.1(fo)4.3(r)-319.7(e)-1.2(valu)4.4(ating)-317.9(t)3.1(he)-320.9(e)4.3(ffe)4.3(c-)]TJ
0 -1.1869 TD
-.0162 Tc
[(tive)-4(ne)-4(ss)-246.5(of)-241.4(a)-244.6(t).3(h)-3.8(e)1.5(rapy)-244.8(on)-242.2(wo)-4(un)-3.8(d)-240.9(p)-2.4(rogre)-4(s)2.8(sion)-242.2(in)-247.7(many)]TJ
0 -1.1923 TD
-.0147 Tc
[(stud)4.5(ies)4.3(.)-243.1(Primary)-243.3(h)-2.3(ealing)-243.3(a).8(nal)4.6(y).6(sis)-245(w)2.1(as)-239.6(performed)-244.8(o)3(n)]TJ
T*
-.0153 Tc
[(the)-409.5(V)-1.9(isitrak)-408.7(d)-1.5(at)-4.3(a)-411.7(a).2(nd)-413.4(the)-415(r)3.5(eported)-413.4(w)-3.9(ound)-413.4(closure)]TJ
0 -1.1869 TD
-.0157 Tc
[(ou)-3.3(tcom)-3.3(es.)-206.2(S)2.3(tat)-4.7(i)3.6(stical)-202.3(an)-3.3(alyses)-202.6(w)-4.3(e)2(re)-204(perfo)-3.5(r)-2.3(med)-207.9(u)2.1(sing)]TJ
0 -1.1923 TD
-.014 Tc
[(S)4(A)-.6(S)-277.8(v)1.3(ers)5(i)-.1(on)-278(9.1.)]TJ
/F2 1 Tf
9.9626 0 0 9.9626 307.8424 504.3967 Tm
0 Tc
[(Seconda)-13.6(ry)-332(outco)-10.1(me)-333.3(analy)-9.7(sis)]TJ
/F5 1 Tf
10.4607 0 0 10.4607 319.8046 491.9243 Tm
[(Serious)-413.6(adverse)-413.4(events,)-411.7(device-related)-415.3(adverse)]TJ
-1.1435 -1.1923 TD
[(events,)-346.7(and)-343.1(complications)-343(were)-346.3(also)-340.4(collected)-349.8(and)]TJ
0 -1.1869 TD
(reported.)Tj
/F2 1 Tf
10.959 0 0 10.959 307.8424 433.644 Tm
(RESULTS)Tj
/F5 1 Tf
10.4607 0 0 10.4607 319.8046 419.6975 Tm
[(This)-470.1(analysis)-471.6(involved)-470.8(40)-473.1(patients)-470.9(\()]TJ
/F7 1 Tf
17.3157 0 TD
(n)Tj
/F6 1 Tf
.7804 0 TD
(=)Tj
/F5 1 Tf
.7154 0 TD
[(19)-473.1(MP)]TJ
-19.955 -1.1923 TD
(NPWT,)Tj
/F7 1 Tf
4.1081 0 TD
(n)Tj
/F6 1 Tf
.7804 0 TD
(=)Tj
/F5 1 Tf
.7208 0 TD
[(21)-700.7(EP)-708(NPWT\))-706.2(who)-701(completed)-708.6(the)]TJ
-5.6093 -1.1869 TD
[(study)-334.9(with)-336(either)-331.2(healing)-332.4(or)-337.4(16)-332.2(weeks)-333(of)-332.2(therapy.)]TJ
0 -1.1923 TD
[(Overall,)-311.6(the)-311.1(average)-307(age)-309.3(was)-311.8(67)-310.5(years)-309.3(and)-310.6(52%)-312.1(of)]TJ
T*
[(patients)-368(were)-362.6(women.)-362.8(Fifteen)-364.5(percent)-366.6(of)-364.7(patients)]TJ
0 -1.1869 TD
[(were)-460.1(smokers)-462.1(and)-456.9(12.5%)-460.1(had)-462.3(coexistent)-457.8(mild)-460.8(to)]TJ
0 -1.1923 TD
[(moderate)-233.1(peripheral)-233.9(artery)-233.4(disease.)-231.1(There)-237.5(were)-232.5(no)]TJ
T*
[(signicant)-310.4(differences)-306(in)-309.7(the)-305.7(baseline)-308(demograph-)]TJ
0 -1.1869 TD
[(ics)-549.8(comparing)-544.1(the)-549.6(MP)-549.4(NPWT)-546(group)-545.2(to)-545.8(the)-549.6(EP)]TJ
0 -1.1923 TD
[(NPWT)-280.5(group)-279.7(\(Table)-277.1(1\).)]TJ
1.1435 -1.1923 TD
[(Despite)-448.3(randomization,)-446.9(there)-453.5(were)-449.3(differences)]TJ
-1.1435 -1.1869 TD
[(in)-347.6(the)-349.1(mean)-348.5(initial)-349.8(wound)-344.2(size)-348.4(\(mean)]TJ
/F6 1 Tf
17.7438 0 TD
()Tj
/F5 1 Tf
.7154 0 TD
[(SD:)-350.8(4.85)]TJ
/F6 1 Tf
4.1352 0 TD
()Tj
/F5 1 Tf
-22.5944 -1.1923 TD
[(4.49)-165.8(cm)]TJ
7.8454 0 0 6.9729 343.7857 274.9038 Tm
(2)Tj
10.4607 0 0 10.4607 350.192 270.2551 Tm
[(for)-205(MP)-202.6(NPWT)-199.2(versus)-201.2(11.60)]TJ
/F6 1 Tf
12.4976 0 TD
()Tj
/F5 1 Tf
.7154 0 TD
[(12.12)-166.6(cm)]TJ
7.8454 0 0 6.9729 530.1353 274.9038 Tm
(2)Tj
10.4607 0 0 10.4607 536.5416 270.2551 Tm
(for)Tj
ET
307.842 223.427 242.079 1.0205 re
f
307.842 58.564 242.079 .51022 re
f
307.842 205.512 242.079 .51024 re
f
BT
/F1 1 Tf
7.9702 0 0 7.9702 307.8424 229.4361 Tm
[(Table)-324.7(1.)]TJ
/F13 1 Tf
4.2679 0 TD
[(Pure)-331.7(venous)-324(leg)-331.3(ulcer)-328.3(comorbid)-324.9(demog)12(raphics)]TJ
/F14 1 Tf
-4.2679 -2.1268 TD
[(Demographic)-9328.5(V.A.C.)]TJ
/F6 1 Tf
5.9774 0 0 5.3127 437.8959 216.0566 Tm
()Tj
/F14 1 Tf
7.9702 0 0 7.9702 479.9621 212.485 Tm
(SNaP)Tj
/F6 1 Tf
5.9774 0 0 5.3127 497.14 216.0566 Tm
()Tj
/F9 1 Tf
7.9702 0 0 7.9702 527.7542 212.485 Tm
(p-)Tj
/F14 1 Tf
.7255 0 TD
(Value)Tj
/F9 1 Tf
-28.3174 -2.1268 TD
[(Age)-332.3(\(mean)]TJ
/F6 1 Tf
4.1683 0 TD
()Tj
/F9 1 Tf
.7113 0 TD
[(SD,)-330.5(years\))-4039.7(66.8)]TJ
/F6 1 Tf
9.5245 0 TD
()Tj
/F9 1 Tf
.7184 0 TD
[(18.1)-333.1(\(21\))-1792.7(67.5)]TJ
/F6 1 Tf
6.7361 0 TD
()Tj
/F9 1 Tf
.7184 0 TD
[(14.8)-333.1(\(19\))-1956.3(0.9045)]TJ
-22.5771 -1.2448 TD
[(Male)-333.4(\(%\))-9452.7(52.4%)-334.6(\(11/21\))-2223(42.1%)-334.5(\(8/19\))-2620.3(0.5450)]TJ
0 -1.2519 TD
[(Race)-333.6(\(%)-331.2(white\))-7176.4(76.2%)-334.6(\(16/21\))-2223(89.5%)-334.5(\(17/19\))-2173.3(0.4124)]TJ
T*
[(Current)-332(smoker)-326.7(\(%\))-6173.6(9.5%)-333.4(\(2/21\))-2670(21.1%)-334.5(\(4/19\))-2620.3(0.3976)]TJ
T*
[(Lower)-327.6(extremity)-329.2(edema)-334.4(\(%\))-2617(76.2%)-334.6(\(16/21\))-2223(68.4%)-334.5(\(13/19\))-2173.3(0.7271)]TJ
0 -1.2448 TD
[(PAD)-326.9(\(%\))-9801.3(14.3%)-334.6(\(3/21\))-2670(10.5%)-334.5(\(2/19\))-2620.3(1.0000)]TJ
0 -1.2519 TD
[(Peripheral)-331.8(neuropathy)-327.1(\(%\))-3264.3(19.0%)-334.6(\(4/21\))-3118.2(5.3%)-333.4(\(1/19\))-2620.3(0.3451)]TJ
T*
[(COPD/asth)10.4(ma)-338.1(\(%\))-6742.6(9.5%)-333.4(\(2/21\))-3118.2(5.3%)-333.4(\(1/19\))-2620.3(1.0000)]TJ
0 -1.2448 TD
[(Cardiac)-326.5(disease)-332.5(\(%\))-5519.1(47.6%)-334.6(\(10/21\))-2223(42.1%)-334.5(\(8/19\))-2620.3(0.7605)]TJ
0 -1.2519 TD
[(Anticoagulat)7.7(ed/coumadin)-333.6(\(%\))-2005.3(33.3%)-334.6(\(7/21\))-2670(36.8%)-334.5(\(7/19\))-2620.3(1.0000)]TJ
T*
[(Immobility)-333.2(\(%\))-7582(23.8%)-334.6(\(5/21\))-2670(26.3%)-334.5(\(5/19\))-2620.3(1.0000)]TJ
T*
[(Steroid)-331(use)-328.6(\(%\))-7567.7(4.8%)-333.4(\(1/21\))-3118.2(5.3%)-333.4(\(1/19\))-2620.3(1.0000)]TJ
0 -1.2448 TD
[(Poor)-334.1(nutrition)-326(\(%\))-6778.2(4.8%)-333.4(\(1/21\))-2670(10.5%)-334.5(\(2/19\))-2620.3(0.5962)]TJ
0 -1.2519 TD
[(Other)-332.2(comorbid)9(ity)-332.4(\(%\))-5241.7(4.8%)-333.4(\(1/21\))-3118.2(5.3%)-333.4(\(1.19\))-2735.3(1.0000)]TJ
/F15 1 Tf
1.003 -2.1197 TD
[(PAD,)-328(peripheral)-329.5(artery)-337.5(disease;)-326.2(SNaP,)-335.9(Smart)-333.2(Negative)-328.7(Pressure;)-331.2(V.A.C.,)]TJ
-1.003 -1.1239 TD
[(Vacuum-A)13.1(ssisted)-332.5(Closure.)]TJ
ET
41.839 753.902 508.082 .51025 re
f
BT
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