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Clinical Evidence

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Introduction

V.A.C.® Therapy Canisters

Clinical outcome of patients with deep sternal wound infection managed by vacuum-assisted closure compared to conventional therapy with open packing: a retrospective analysis
V.A.C.® Therapy can improve the medical outcome of patients with mediastinitis compared with the conventional technique of open packing.
Comparison of Negative Pressure Wound Therapy Using Vacuum-Assisted Closure With Advanced Moist Wound Therapy in the Treatment of Diabetic Foot Ulcers
This study of 342 patients with diabetic foot ulcers showed that V.A.C.® Therapy is as safe as and more efficacious than advanced moist wound therapy for the treatment of diabetic foot ulcers.
Use of Vacuum Assisted Closure Therapy in the Treatment of Diabetic Foot Wounds
Treating diabetic wounds with V.A.C.® Therapy can result in faster wound bed preparation, a faster closure, and in a better graft take rate when compared to standard wound care.
Comparison of Health Care Costs and Hospital Readmission Rates Associated With Negative Pressure Wound Therapies
In comparison with non-KCI models of NPWT, this retrospective analysis showed that NPWT patients treated with V.A.C.® Therapy had lower hospital readmission rates, lower total costs and lower wound related costs.
Negative Pressure Wound Therapy after partial diabetic foot amputation: a multicentre, randomised controlled trial
V.A.C.® Therapy could lead to a higher proportion of healed wounds, faster healing rates, and potentially fewer re-amputations than standard of care.
A Prospective Randomized Trial of Vacuum-Assisted Closure Versus Standard Therapy of Chronic Nonhealing Wounds
V.A.C.® Therapy treated wounds are characterized by granulation tissue formation and reduced wound depth and volume.
Vacuum-assisted closure versus saline-moistened gauze in the healing of postoperative diabetic foot wounds
On average, V.A.C.® Therapy patients attained satisfactory healing of post-operative diabetic wounds via definitive closure approximately 3 weeks sooner than saline moistened gauze-treated patients.
A prospective randomized evaluation of negative-pressure wound dressings for diabetic foot wounds
V.A.C.® Therapy decreased wound depth and volume more effectively than moist gauze dressings.
A randomised study of NPWT closure versus alginate dressings in peri-vascular groin infections: quality of life, pain and cost.

In patients with deep peri-vascular groin infection, NPWT therapy was regarded as the dominant strategy, due to improved clinical outcome, with equal measures of cost and quality of life.

State-of-the-art treatment of chronic leg ulcers: A randomized controlled trial comparing vacuum-assisted closure (V.A.C.®) with modern wound dressings
V.A.C.® Therapy should be considered as the treatment of choice for chronic leg ulcers as it reduces the time to complete healing and the duration of wound bed preparation.